/s/ Dinesh V. Patel Dinesh V. Patel, Ph.D. President and Chief Executive Officer |
Proposal Number | | | Proposal Description | | | Vote Required for Approval | | | Effect of Abstentions | | | Effect of Broker Non-Votes | |
1 | | | Election of | | | | | Under plurality voting, there are no abstentions. | | | None | | |
2 | | | Advisory approval of the compensation of our named executive officers | | | “For” votes from the holders of a majority of shares present online during the virtual meeting or represented by proxy and entitled to vote on the matter. | | | Against | | | None | |
3 | | | |||||||||||
Ratification of the selection of Ernst & Young LLP as the Company’s independent auditor for fiscal year ending December 31, | | | “For” votes from the holders of a majority of shares present online during the virtual meeting or represented by proxy and entitled to vote on the matter. | | | Against | | | None | |
Name | | | Audit | | | Compensation | | | Nominating and Corporate Governance | | |||||||||
Bryan Giraudo | | | | | X | | | | | | — | | | | | | X* | | |
Sarah Noonberg, M.D., Ph.D | | | | | X | | | | | | — | | | | | | — | | |
Sarah A. O’Dowd | | | | | — | | | | | | — | | | | | | X | | |
Dinesh V. Patel, Ph.D | | | | | — | | | | | | — | | | | | | — | | |
Harold E. Selick, Ph.D | | | | | — | | | | | | X* | | | | | | X | | |
William D. Waddill | | | | | X* | | | | | | X | | | | | | — | | |
Lewis T. Williams, M.D., Ph.D | | | | | — | | | | | | X | | | | | | — | | |
Total meetings in fiscal 2021 | | | | | 6 | | | | | | 5 | | | | | | 2 | | |
Name | | | Audit | | | Compensation | | | Nominating and Corporate Governance | | |||||||||
Bryan Giraudo | | | | | X | | | | | | — | | | | | | X* | | |
Sarah Noonberg, M.D., Ph.D.(1) | | | | | X | | | | | | — | | | | | | — | | |
Sarah A. O’Dowd | | | | | — | | | | | | — | | | | | | X | | |
Dinesh V. Patel, Ph.D. | | | | | — | | | | | | — | | | | | | — | | |
Harold E. Selick, Ph.D. | | | | | — | | | | | | X* | | | | | | X | | |
William D. Waddill | | | | | X* | | | | | | X | | | | | | — | | |
Lewis T. Williams, M.D., Ph.D. | | | | | — | | | | | | X | | | | | | — | | |
Total meetings in fiscal 2022 | | | | | 6 | | | | | | 3 | | | | | | 4 | | |
Board Diversity Matrix (as of April 13) | | ||||||||||||||||||||||||
Total number of directors – 7 | | | | | | | | | | | | | | | | | | | | | |||||
Gender identity: | | | Female | | | Male | | | Non- Binary | | | Did not Disclose Gender | | ||||||||||||
Directors | | | | | 2 | | | | | | 5 | | | | | | — | | | | | | — | | |
Number of directors who identify in any of the categories below: | | | | | | | | | | | | | | | | | | | | | | | | | |
African American or Black | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
Alaskan Native or Native American | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
Asian | | | | | — | | | | | | 1 | | | | | | — | | | | | | — | | |
Hispanic or Latinx | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
Native Hawaiian or Pacific Islander | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
White | | | | | 2 | | | | | | 4 | | | | | | — | | | | | | — | | |
Two or More Races or Ethnicities | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
LGBTQ+ | | | — | |
| Board Diversity Matrix (as of April 12) | |
| Total number of directors – 7 | |
Gender identity: | | | Female | | | Male | | | Non- Binary | | | Did not Disclose Gender | | ||||||||||||
Directors | | | | | 2 | | | | | | 5 | | | | | | — | | | | | | — | | |
Number of directors who identify in any of the categories below: | | | | | | | | | | | | | | | | | | | | | | | | | |
African American or Black | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
Alaskan Native or Native American | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
Asian | | | | | — | | | | | | 1 | | | | | | — | | | | | | — | | |
Hispanic or Latinx | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
Native Hawaiian or Pacific Islander | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
White | | | | | 2 | | | | | | 4 | | | | | | — | | | | | | — | | |
Two or More Races or Ethnicities | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
LGBTQ+ | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
| | Fiscal Year Ended December 31, | | | Fiscal Year Ended December 31, | | ||||||||||||||||||||
| | 2021 | | 2020 | | | 2022 | | 2021 | | ||||||||||||||||
Audit Fees(1) | | | $ | 1,507,376 | | | | $ | 860,675 | | | | | $ | 1,035,150 | | | | $ | 1,507,376 | | | ||||
Audit-Related Fees(2) | | | | — | | | | | — | | | | | | — | | | | | — | | | ||||
Tax Fees(3) | | | | 27,605 | | | | | 80,798 | | | | | | 20,639 | | | | | 27,605 | | | ||||
All Other Fees(4) | | | | — | | | | | — | | | | | | 3,405 | | | | | — | | | ||||
Total Fees | | | $ | 1,534,981 | | | | $ | 941,473 | | | | | $ | 1,059,194 | | | | $ | 1,534,981 | | |
Name | | | AUD: USD | | | AUD | | | USD | | |||||||||
2021 Average | | | | | 1.00:0.75144 | | | | | $ | 26,000 | | | | | $ | 19,538 | | |
2020 Average | | | | | 1.00:0.70348 | | | | | $ | 114,855 | | | | | $ | 80,798 | | |
Name | | | Age | | | Position | | |||
Dinesh V. Patel, | | | | 66 | | | | President, Chief Executive Officer and Director | | |
| | | | | ||||||
| | Executive Vice President, Chief Financial Officer | | |||||||
Suneel Gupta, Ph.D. | | | | | 65 | | | | Chief Development Officer | |
Arturo Molina, M.D., M.S., F.A.C.P. | | | | | 64 | | | | Chief Medical Officer | |
| | | Beneficial Ownership(1) | | |||||||||
Beneficial Owner | | | Number of Shares | | | Percent of Total | | ||||||
5% Stockholders: | | | | | | | | | | | | | |
FMR LLC(2) | | | | | 6,847,277 | | | | | | 14.1% | | |
Biotechnology Value Fund, L.P. and its affiliated entities(3) | | | | | 4,983,759 | | | | | | 10.3% | | |
Farallon Partners, L.L.C.(4) | | | | | 3,417,134 | | | | | | 7.0% | | |
BlackRock, Inc.(5) | | | | | 3,281,636 | | | | | | 6.8% | | |
RTW Investments, LP(6) | | | | | 2,599,822 | | | | | | 5.4% | | |
State Street Corporation(7) | | | | | 2,571,570 | | | | | | 5.3% | | |
Johnson & Johnson Development Corporation(8) | | | | | 2,449,183 | | | | | | 5.0% | | |
Point 72 Asset Management, L.P. and its affiliated entities(9) | | | | | 2,420,309 | | | | | | 5.0% | | |
Named Executive Officers and Directors: | | | | | | | | | | | | | |
Dinesh V. Patel, Ph.D.(10) | | | | | 1,457,952 | | | | | | 2.9% | | |
Suneel Gupta, Ph.D.(11) | | | | | 250,327 | | | | | | * | | |
David Y. Liu, Ph.D.(12) | | | | | 411,000 | | | | | | * | | |
Harold E. Selick, Ph.D.(13) | | | | | 128,020 | | | | | | * | | |
Bryan Giraudo(14) | | | | | 81,000 | | | | | | * | | |
Sarah Noonberg, M.D., Ph.D.(15) | | | | | 54,600 | | | | | | * | | |
Sarah A. O’Dowd(16) | | | | | 17,500 | | | | | | * | | |
William D. Waddill(17) | | | | | 87,975 | | | | | | * | | |
Lewis T. Williams, M.D., Ph.D.(18) | | | | | 63,000 | | | | | | * | | |
All executive officers and directors as a group (10 persons)(19) | | | | | 2,675,518 | | | | | | 5.3% | | |
| | | Beneficial Ownership(1) | | |||||||||
Beneficial Owner | | | Number of Shares | | | Percent of Total | | ||||||
5% Stockholders: | | | | | | | | | | | | | |
Farallon Partners, L.L.C. and its affiliated entities(2) | | | | | 5,151,887 | | | | | | 9.7% | | |
Biotechnology Value Fund, L.P. and its affiliated entities(3) | | | | | 5,025,900 | | | | | | 9.5% | | |
State Street Corporation and its affiliated entities(4) | | | | | 3,792,926 | | | | | | 7.4% | | |
BlackRock, Inc.(5) | | | | | 3,652,157 | | | | | | 7.1% | | |
RTW Investments, L.P.(6) | | | | | 3,591,986 | | | | | | 7.0% | | |
The Vanguard Group, Inc.(7) | | | | | 3,097,714 | | | | | | 6.0% | | |
Citadel Advisors LLC and its affiliated entities(8) | | | | | 2,682,814 | | | | | | 5.2% | | |
Named Executive Officers and Directors: | | | | | | | | | | | | | |
Dinesh V. Patel, Ph.D.(9) | | | | | 1,706,580 | | | | | | 3.2% | | |
Suneel Gupta, Ph.D.(10) | | | | | 354,461 | | | | | | * | | |
David Y. Liu, Ph.D.(11) | | | | | 483,479 | | | | | | * | | |
Harold E. Selick, Ph.D.(12) | | | | | 153,520 | | | | | | * | | |
Bryan Giraudo(13) | | | | | 106,500 | | | | | | * | | |
Sarah Noonberg, M.D., Ph.D.(14) | | | | | 80,100 | | | | | | * | | |
Sarah A. O’Dowd(15) | | | | | 53,000 | | | | | | * | | |
William D. Waddill(16) | | | | | 113,475 | | | | | | * | | |
Lewis T. Williams, M.D., Ph.D.(17) | | | | | 88,500 | | | | | | * | | |
All current executive officers and directors as a group (10 persons)(18) | | | | | 2,681,916 | | | | | | 5.0% | | |
Name and Principal Position | | Year | | Salary ($)(1) | | Stock Awards ($)(2)(3) | | Option Awards ($)(2) | | Non-Equity Incentive Plan Compensation ($)(4) | | All Other Compensation ($)(5) | | Total ($) | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Non-Equity Principal Position | | Year | | Salary ($)(1) | | Stock Awards ($)(2)(3) | | Option Awards ($)(2) | | Non-Equity Incentive Plan Compensation ($)(4) | | All Other Compensation ($)(5) | | Total ($) | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Dinesh V. Patel, Ph.D. President and Chief Executive Officer | | | | | 2021 | | | | | 600,000 | | | | | 589,250 | | | | | 3,919,365 | | | | | 429,000 | | | | | 7,118 | | | | | 5,544,733 | | | | | | | 2022 | | | | | 630,000 | | | | | 897,813 | | | | | 4,211,963 | | | | | 242,550 | | | | | 10,912 | | | | | 5,993,238 | | | ||||||||||||
| | | 2020 | | | | | 565,000 | | | | | — | | | | | 1,183,155 | | | | | 473,894 | | | | | 3,573 | | | | | 2,225,622 | | | | | | 2021 | | | | | 600,000 | | | | | 589,250 | | | | | 3,919,365 | | | | | 429,000 | | | | | 7,118 | | | | | 5,544,733 | | | |||||||||||||||
David Y. Liu, Ph.D. Chief Research and Development Strategy Officer (6) | | | | | 2021 | | | | | 455,000 | | | | | 235,700 | | | | | 1,132,261 | | | | | 233,188 | | | | | 14,678 | | | | | 2,070,827 | | | |||||||||||||||||||||||||||||||||||||||||||||||||
| | | 2020 | | | | | 441,300 | | | | | — | | | | | 352,429 | | | | | 266,987 | | | | | 11,133 | | | | | 1,071,849 | | | |||||||||||||||||||||||||||||||||||||||||||||||||||
Suneel Gupta, Ph.D Chief Development Officer | | | | | 2021 | | | | | 455,000 | | | | | 282,840 | | | | | 1,393,552 | | | | | 236,600 | | | | | 7,118 | | | | | 2,375,110 | | | |||||||||||||||||||||||||||||||||||||||||||||||||
| | | 2020 | | | | | 420,000 | | | | | — | | | | | 427,950 | | | | | 256,200 | | | | | 4,120 | | | | | 1,108,270 | | | |||||||||||||||||||||||||||||||||||||||||||||||||||
Suneel Gupta, Ph.D. Chief Development Officer | | | | | 2022 | | | | | 500,000 | | | | | 359,125 | | | | | 1,684,785 | | | | | 130,000 | | | | | 10,894 | | | | | 2,684,804 | | | |||||||||||||||||||||||||||||||||||||||||||||||||
| | | 2021 | | | | | 455,000 | | | | | 282,840 | | | | | 1,393,552 | | | | | 236,600 | | | | | 7,118 | | | | | 2,375,110 | | | |||||||||||||||||||||||||||||||||||||||||||||||||||
David Y. Liu, Ph.D. Former Chief Research and Development Strategy Officer (6) | | | | | 2022 | | | | | 475,000 | | | | | 287,300 | | | | | 1,347,828 | | | | | 123,500 | | | | | 15,178 | | | | | 2,248,806 | | | |||||||||||||||||||||||||||||||||||||||||||||||||
| | | 2021 | | | | | 455,000 | | | | | 235,700 | | | | | 1,132,261 | | | | | 233,188 | | | | | 14,678 | | | | | 2,070,827 | | |
Name | | 2021 Base Salary ($) | | Target Bonus (as a % of base salary) | | Amount of Bonus Earned ($) | | | 2022 Base Salary ($) | | Target Bonus (as a% of base salary) | | Amount of Bonus Earned ($) | | ||||||||||||||||||||||||
Dinesh V. Patel, Ph.D | | | | 600,000 | | | | | 55% | | | | | 429,000 | | | ||||||||||||||||||||||
Dinesh V. Patel, Ph.D. | | | | 630,000 | | | | | 55% | | | | | 242,550 | | | ||||||||||||||||||||||
Suneel Gupta, Ph.D. | | | | 500,000 | | | | | 40% | | | | | 130,000 | | | ||||||||||||||||||||||
David Y. Liu, Ph.D. | | | | 455,000 | | | | | 40% | | | | | 233,188 | | | | | | 475,000 | | | | | 40% | | | | | 123,500 | | | ||||||
Suneel Gupta, Ph.D | | | | 455,000 | | | | | 40% | | | | | 236,600 | | |
| | | Option Awards | | | Stock Awards | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Equity Incentive Plan Awards: | | |||||||||
| | | Grant Date | | | Number of Securities Underlying Unexercised Options (#) Exercisable | | | Number of Securities Underlying Unexercised Options (#) Unexercisable | | | Option Exercise Price ($) | | | Vesting Commencement Date | | | Option Expiration Date | | | Number of Shares or Units of Stock That Have Not Vested (#) | | | Market Value of Shares or Units of Stock That Have Not Vested ($) | | | Number of Unearned Shares, Units or Other Rights That Have Not Vested (#) | | | Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Yet Vested ($) | | ||||||||||||||||||||||||||||||
Dinesh V. Patel, Ph.D. | | | | | 04/29/2016 | | | | | | 60,000 | | | | | | — | | | | | $ | 4.21 | | | | | | 04/25/2016 | | | | | | 04/28/2026 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
| | | 10/11/2016 | | | | | | 320,000 | | | | | | — | | | | | $ | 21.58 | | | | | | 08/10/2016 | | | | | | 10/10/2026 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/28/2018 | | | | | | 150,000 | | | | | | — | | | | | $ | 16.95 | | | | | | 02/28/2018 | | | | | | 02/27/2028 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 08/15/2018 | | | | | | 54,700 | | | | | | — | | | | | $ | 8.58 | | | | | | 08/05/2018 | | | | | | 08/14/2028 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/28/2019(1)(2) | | | | | | 165,312 | | | | | | 7,188 | | | | | $ | 8.02 | | | | | | 02/28/2019 | | | | | | 02/27/2029 | | | | | | 7,188 | | | | | | 78,421 | | | | | | — | | | | | | — | | | ||
| | | 02/28/2020(1) | | | | | | 166,458 | | | | | | 68,542 | | | | | $ | 7.80 | | | | | | 02/28/2020 | | | | | | 02/27/2030 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/26/2021(1)(3)(4) | | | | | | 103,125 | | | | | | 121,875 | | | | | $ | 23.57 | | | | | | 02/26/2021 | | | | | | 02/25/2031 | | | | | | 25,000 | | | | | | 272,750 | | | | | | 25,000 | | | | | | 272,750 | | | ||
| | | 02/15/2022(1)(5) | | | | | | 39,062 | | | | | | 148,438 | | | | | $ | 28.73 | | | | | | 02/15/2022 | | | | | | 02/14/2032 | | | | | | 31,250 | | | | | | 340,938 | | | | | | — | | | | | | — | | | ||
| | | 05/31/2022(6) | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 30,000 | | | | | | 327,300 | | | ||
Suneel Gupta, Ph.D. | | | | | 01/15/2019(7) | | | | | | 67,708 | | | | | | 2,292 | | | | | $ | 7.38 | | | | | | 01/07/2019 | | | | | | 01/14/2029 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
| | | 02/28/2019(1)(2) | | | | | | 43,125 | | | | | | 1,875 | | | | | $ | 8.02 | | | | | | 02/28/2019 | | | | | | 02/27/2029 | | | | | | 1,875 | | | | | | 20,456 | | | | | | — | | | | | | — | | | ||
| | | 02/28/2020(1) | | | | | | 60,208 | | | | | | 27,792 | | | | | $ | 7.80 | | | | | | 02/28/2020 | | | | | | 02/27/2030 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/26/2021(1)(3)(4) | | | | | | 36,666 | | | | | | 43,334 | | | | | $ | 23.57 | | | | | | 02/26/2021 | | | | | | 02/25/2031 | | | | | | 12,000 | | | | | | 130,920 | | | | | | 12,000 | | | | | | 130,920 | | | ||
| | | 02/15/2022(1)(5) | | | | | | 15,625 | | | | | | 59,375 | | | | | $ | 28.73 | | | | | | 02/15/2022 | | | | | | 02/14/2032 | | | | | | 12,000 | | | | | | 136,375 | | | | | | — | | | | | | — | | | ||
| | | 05/31/2022(6) | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 12,000 | | | | | | 130,920 | | | ||
David Y. Liu, Ph.D. | | | | | 10/11/2016 | | | | | | 65,000 | | | | | | — | | | | | $ | 21.58 | | | | | | 08/10/2016 | | | | | | 10/10/2026 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
| | | 02/28/2018 | | | | | | 56,500 | | | | | | — | | | | | $ | 16.95 | | | | | | 02/28/2018 | | | | | | 02/27/2028 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 08/15/2018 | | | | | | 17,200 | | | | | | — | | | | | $ | 8.58 | | | | | | 08/05/2018 | | | | | | 08/14/2028 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/28/2019(1)(2) | | | | | | 86,250 | | | | | | 3,750 | | | | | $ | 8.02 | | | | | | 02/28/2019 | | | | | | 02/27/2029 | | | | | | 3,750 | | | | | | 40,913 | | | | | | — | | | | | | — | | | ||
| | | 02/28/2020(1) | | | | | | 49,583 | | | | | | 20,417 | | | | | $ | 7.80 | | | | | | 02/28/2020 | | | | | | 02/27/2030 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/26/2021(1)(3)(4) | | | | | | 29,791 | | | | | | 35,209 | | | | | $ | 23.57 | | | | | | 02/26/2021 | | | | | | 02/25/2031 | | | | | | 10,000 | | | | | | 109,100 | | | | | | 10,000 | | | | | | 109,100 | | | ||
| | | 02/15/2022(1)(5) | | | | | | 12,500 | | | | | | 47,500 | | | | | $ | 28.73 | | | | | | 02/15/2022 | | | | | | 02/14/2032 | | | | | | 10,000 | | | | | | 109,100 | | | | | | — | | | | | | — | | | ||
| | | 05/31/2022(6) | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 12,000 | | | | | | 130,920 | | |
| | | Option Awards | | | Stock Awards | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Equity Incentive Incentive Plan Awards: | | |||||||||
| | | Grant Date | | | Number of Securities Underlying Unexercised Options (#) Exercisable | | | Number of Securities Underlying Unexercised Options (#) Unexercisable | | | Option Exercise Price ($) | | | Vesting Commencement Date | | | Option Expiration Date | | | Number of Shares or Units of Stock That Have Not Vested (#) | | | Market Value of Shares or Units of Stock That Have Not Vested ($) | | | Number of Unearned Shares, Units or Other Rights That Have Not Vested (#) | | | Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Yet Vested ($) | | ||||||||||||||||||||||||||||||
Dinesh V. Patel, Ph.D. | | | | | 10/22/2014(1) | | | | | | 34,087 | | | | | | — | | | | | $ | 1.89 | | | | | | 11/01/2014 | | | | | | 10/21/2024 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
| | | 04/29/2016(2) | | | | | | 125,742 | | | | | | — | | | | | $ | 4.21 | | | | | | 04/25/2016 | | | | | | 04/28/2026 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 10/11/2016(2) | | | | | | 320,000 | | | | | | — | | | | | $ | 21.58 | | | | | | 08/10/2016 | | | | | | 10/10/2026 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/28/2018(2)(3) | | | | | | 143,750 | | | | | | 6,250 | | | | | $ | 16.95 | | | | | | 02/28/2018 | | | | | | 02/27/2028 | | | | | | 6,250 | | | | | | 213,750 | | | | | | — | | | | | | — | | | ||
| | | 08/15/2018(4) | | | | | | 54,700 | | | | | | — | | | | | $ | 8.58 | | | | | | 08/05/2018 | | | | | | 08/14/2028 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/28/2019(2)(3) | | | | | | 122,187 | | | | | | 50,313 | | | | | $ | 8.02 | | | | | | 02/28/2019 | | | | | | 02/27/2029 | | | | | | 14,376 | | | | | | 491,659 | | | | | | — | | | | | | — | | | ||
| | | 02/28/2020(2) | | | | | | 107,708 | | | | | | 127,292 | | | | | $ | 7.80 | | | | | | 02/28/2020 | | | | | | 02/27/2030 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/26/2021(2)(5)(6) | | | | | | 46,875 | | | | | | 178,125 | | | | | $ | 23.57 | | | | | | 02/26/2021 | | | | | | 02/25/2031 | | | | | | 25,000 | | | | | | 855,000 | | | | | | 25,000 | | | | | | 855,000 | | | ||
David Y. Liu, Ph.D. | | | | | 09/26/2013(1) | | | | | | 13,767 | | | | | | — | | | | | $ | 0.87 | | | | | | 06/01/2013 | | | | | | 09/25/2023 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
| | | 10/22/2014(1) | | | | | | 9,726 | | | | | | — | | | | | $ | 1.89 | | | | | | 11/01/2014 | | | | | | 10/21/2024 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 03/26/2015(2) | | | | | | 5,999 | | | | | | — | | | | | $ | 1.89 | | | | | | 03/26/2015 | | | | | | 03/25/2025 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 10/28/2015(2) | | | | | | 36,656 | | | | | | — | | | | | $ | 1.16 | | | | | | 09/01/2015 | | | | | | 10/27/2025 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 04/29/2016(2) | | | | | | 35,331 | | | | | | — | | | | | $ | 4.21 | | | | | | 04/25/2016 | | | | | | 04/28/2026 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 10/11/2016(2) | | | | | | 65,000 | | | | | | — | | | | | $ | 21.58 | | | | | | 08/10/2016 | | | | | | 10/10/2026 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/28/2018(2)(3) | | | | | | 54,145 | | | | | | 2,355 | | | | | $ | 16.95 | | | | | | 02/28/2018 | | | | | | 02/27/2028 | | | | | | 2,375 | | | | | | 81,225 | | | | | | — | | | | | | — | | | ||
| | | 08/15/2018(4) | | | | | | 17,200 | | | | | | — | | | | | $ | 8.58 | | | | | | 08/05/2018 | | | | | | 08/14/2028 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/28/2019(2)(3) | | | | | | 63,750 | | | | | | 26,250 | | | | | $ | 8.02 | | | | | | 02/28/2019 | | | | | | 02/27/2029 | | | | | | 7,500 | | | | | | 256,500 | | | | | | — | | | | | | — | | | ||
| | | 02/28/2020(2) | | | | | | 32,083 | | | | | | 37,917 | | | | | $ | 7.80 | | | | | | 02/28/2020 | | | | | | 02/27/2030 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/26/2021(2)(5)(6) | | | | | | 13,541 | | | | | | 51,459 | | | | | $ | 23.57 | | | | | | 02/26/2021 | | | | | | 02/25/2031 | | | | | | 10,000 | | | | | | 342,000 | | | | | | 10,000 | | | | | | 342,000 | | | ||
Suneel Gupta, Ph.D. | | | | | 01/15/2019(1) | | | | | | 80,208 | | | | | | 29,792 | | | | | $ | 7.38 | | | | | | 01/07/2019 | | | | | | 01/14/2029 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | |
| | | 02/28/2019(2)(3) | | | | | | 31,875 | | | | | | 13,125 | | | | | $ | 8.02 | | | | | | 02/28/2019 | | | | | | 02/27/2029 | | | | | | 3,750 | | | | | | 128,250 | | | | | | — | | | | | | — | | | ||
| | | 02/28/2020(2) | | | | | | 38,958 | | | | | | 46,042 | | | | | $ | 7.80 | | | | | | 02/28/2020 | | | | | | 02/27/2030 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | ||
| | | 02/26/2021(2)(5)(6) | | | | | | 16,666 | | | | | | 63,334 | | | | | $ | 23.57 | | | | | | 02/26/2021 | | | | | | 02/25/2031 | | | | | | 12,000 | | | | | | 410,400 | | | | | | 12,000 | | | | | | 410,400 | | |
Year | | | Summary Compensation Table Total for PEO(1) | | | Compensation Actually Paid to PEO(2) | | | Average Summary Compensation Table Total for Non-PEO NEOs(3) | | | Average Compensation Actually Paid to Non-PEO NEOs(4) | | | Value of Initial Fixed $100 Investment Based On Total Shareholder Return(5) | | | Net Loss(6) | | ||||||||||||||||||
2022 | | | | $ | 5,993,238 | | | | | $ | (5,174,369) | | | | | $ | 2,466,805 | | | | | $ | (1,687,548) | | | | | $ | 54.12 | | | | | $ | (127,393,315) | | |
2021 | | | | $ | 5,544,733 | | | | | $ | 12,111,993 | | | | | $ | 2,222,969 | | | | | $ | 4,761,991 | | | | | $ | 169.64 | | | | | $ | (125,550,748) | | |
Year | | | Reported Summary Compensation Table Total for PEO | | | Reported Value of Equity Awards(a) | | | Equity Award Adjustments(b) | | | Compensation Actually Paid to PEO | | ||||||||||||
2022 | | | | $ | 5,993,238 | | | | | $ | (5,109,776) | | | | | $ | (6,057,831) | | | | | $ | (5,174,369) | | |
2021 | | | | $ | 5,544,733 | | | | | $ | (4,508,615) | | | | | $ | 11,075,875 | | | | | $ | 12,111,993 | | |
Year | | | Year End Fair Value of Outstanding and Unvested Equity Awards Granted During the Year | | | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Years | | | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year | | | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year | | | Total Equity Award Adjustments | | |||||||||||||||
2022 | | | | $ | 1,538,304 | | | | | $ | (4,758,042) | | | | | $ | 328,901 | | | | | $ | (3,166,994) | | | | | $ | (6,057,831) | | |
2021 | | | | $ | 5,481,885 | | | | | $ | 2,690,740 | | | | | $ | 1,252,857 | | | | | $ | 1,650,393 | | | | | $ | 11,075,875 | | |
Year | | | Average Reported Summary Compensation Table Total for Non-PEO NEOs | | | Average Reported Value of Equity Awards | | | Average Equity Award Adjustments(a) | | | Average Compensation Actually Paid to Non-PEO NEOs | | ||||||||||||
2022 | | | | $ | 2,466,805 | | | | | $ | (1,839,519) | | | | | $ | (2,314,834) | | | | | $ | (1,687,548) | | |
2021 | | | | $ | 2,222,969 | | | | | $ | (1,522,177) | | | | | $ | 4,061,199 | | | | | | 4,761,991 | | |
Year | | | Average Year End Fair Value of Outstanding and Unvested Equity Awards Granted During the Year | | | Year over Year Average Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Years | | | Average Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year | | | Year over Year Average Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year | | | Total Average Equity Award Adjustments | | |||||||||||||||
2022 | | | | $ | 553,787 | | | | | $ | (1,661,551) | | | | | $ | 118,408 | | | | | $ | (1,325,478) | | | | | $ | (2,314,834) | | |
2021 | | | | $ | 1,867,101 | | | | | | 1,110,914 | | | | | $ | 403,689 | | | | | $ | 679,495 | | | | | $ | 4,061,199 | | |
Name | | Fees Earned or Paid in Cash ($) | | Option Awards ($)(1)(2) | | Total ($) | | | Fees Earned or Paid in Cash ($) | | Option Awards ($)(1)(2) | | Total ($) | | ||||||||||||||||||||||||
Bryan Giraudo | | | | 60,000 | | | | | 448,011 | | | | | 508,011 | | | | | | 60,000 | | | | | 128,940 | | | | | 188,940 | | | ||||||
Sarah Noonberg, M.D., Ph.D. | | | | 50,000 | | | | | 448,011 | | | | | 498,011 | | | | | | 50,000 | | | | | 128,940 | | | | | 178,940 | | | ||||||
Sarah A. O’Dowd | | | | 45,000 | | | | | 448,011 | | | | | 493,011 | | | | | | 45,000 | | | | | 128,940 | | | | | 173,940 | | | ||||||
Harold E. Selick, Ph.D | | | | 95,000 | | | | | 448,011 | | | | | 543,011 | | | ||||||||||||||||||||||
Harold E. Selick, Ph.D. | | | | 95,000 | | | | | 128,940 | | | | | 223,940 | | | ||||||||||||||||||||||
William D. Waddill | | | | 67,500 | | | | | 448,011 | | | | | 515,511 | | | | | | 67,500 | | | | | 128,940 | | | | | 196,440 | | | ||||||
Lewis T. Williams, M.D., Ph.D. | | | | 47,500 | | | | | 448,011 | | | | | 494,511 | | | | | | 47,500 | | | | | 128,940 | | | | | 176,440 | | |
Name | | | Aggregate Number of Option Awards Outstanding as of December 31, | | |||
Bryan Giraudo | | | | | | | |
Sarah Noonberg, M.D., Ph.D. | | | | | | | |
Sarah A. O’Dowd | | | | | | | |
Harold E. Selick, | | | | | | | |
William D. Waddill | | | | | | | |
Lewis T. Williams, M.D. | | | | | | |
Plan Category(1) | | Number of securities to be issued upon exercise of outstanding options, warrants and rights (a) | | Weighted average exercise price of outstanding options, warrants and rights(6) (b) | | Number of securities remaining available for issuance under equity compensation plans (excluding securities reflected in column (a)) (c) | | | Number of securities to be issued upon exercise of outstanding options, warrants and rights (a) | | Weighted average exercise price of outstanding options, warrants and rights(6) (b) | | Number of securities remaining available for issuance under equity compensation plans (excluding securities reflected in column (a)) (c) | | ||||||||||||||||||||||||
Equity compensation plans approved by securities holders: | | | | | | | | | | | | | | | | | ||||||||||||||||||||||
Equity compensation plans approved by securities holders: | | | | | | | | | | | | | | | | | ||||||||||||||||||||||
2007 Stock Option and Incentive Plan | | | | 396,401(3) | | | | $ | 3.35 | | | | | — | | | | | | 167,828(3) | | | | $ | 3.78 | | | | | — | | | ||||||
2016 Equity Incentive Plan | | | | 5,095,361(4) | | | | $ | 18.19 | | | | | 564,189(7) | | | | | | 5,914,150(4) | | | | $ | 19.20 | | | | | 1,350,793(7) | | | ||||||
2016 Employee Stock Purchase Plan | | | | — | | | | | — | | | | | 1,013,999(8) | | | | | | — | | | | | — | | | | | 1,255,290(8) | | | ||||||
Equity compensation plans not approved by securities holders: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | ||||||
2018 Inducement Plan(2) | | | | 910,250(5) | | | | $ | 21.32 | | | | | 243,125 | | | | | | 995,467(5) | | | | $ | 20.85 | | | | | 574,772 | | | ||||||
Total | | | | 6,402,012 | | | | $ | 17.66 | | | | | 1,821,313 | | | | | | 7,077,445 | | | | $ | 19.03 | | | | | 3,180,855 | | |